Chromatin-based Mechanisms of Renal Epithelial Differentiation | Zendy

Kameswaran Surendran | Zendy; Raphael Kopan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Chromatin-based Mechanisms of Renal Epithelial Differentiation

Author(s) -

Kameswaran Surendran,

Raphael Kopan

Publication year - 2011

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2010101018

Subject(s) - mesenchyme , biology , epigenetics , chromatin , progenitor cell , regenerative medicine , cellular differentiation , phenotype , microbiology and biotechnology , induced pluripotent stem cell , population , psychological repression , gene , stem cell , genetics , gene expression , embryonic stem cell , mesenchymal stem cell , medicine , environmental health

Successful regenerative renal medicine depends on understanding the molecular mechanisms by which diverse phenotypes of epithelial cells differentiate from metanephric mesenchyme to populate nephrons. Whereas many genes are maintained in a poised state within the population of pluripotent progenitors, specialized epithelial functions reflect the selective expression of a subset of genes and the repression of all others. Here we highlight some common mechanisms of cell differentiation and epigenetic regulation to discuss their implications for renal epithelial development, repair, and disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research