Open AccessResolved
Author(s) -
Michael Zeisberg,
Jeremy S. Duffield
Publication year - 2010
Publication title -
journal of the american society of nephrology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2010060616
Subject(s) - gastrulation , mesenchymal stem cell , epithelial–mesenchymal transition , metastasis , cancer research , microbiology and biotechnology , biology , pathology , cancer , medicine , embryogenesis , embryo
Epithelial-mesenchymal transition (EMT) is a mechanism for generating primitive mesenchymal cells during gastrulation or mobile tumor cells during cancer metastasis. For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate.