Open AccessTCF7L2 Polymorphism Associates with New-Onset Diabetes after Transplantation
Author(s) -
Lidia Ghisdal,
Christophe Baron,
Yann Le Meur,
Arnaud Lionet,
JeanMichel Halimi,
Jean-Philippe Rérolle,
François Glowacki,
Yvon Lebranchu,
M Drouet,
Christian Noël,
Hakim El Housni,
Pascale Cochaux,
Karl Martin Wissing,
Daniel Abramowicz,
Marc Abramowicz
Publication year - 2009
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2008121314
Subject(s) - tcf7l2 , medicine , transplantation , diabetes mellitus , odds ratio , gastroenterology , type 2 diabetes , population , tacrolimus , body mass index , genotype , endocrinology , biology , genetics , single nucleotide polymorphism , environmental health , gene
New-onset diabetes after transplantation (NODAT) is a serious and frequent complication in transplant recipients. Whether NODAT shares the same susceptibility genes as type 2 diabetes is unknown. In this multicenter study, we genotyped 1076 white patients without diabetes at transplantation for 11 polymorphisms that associate with type 2 diabetes. We defined NODAT as a fasting plasma glucose > or =126 mg/dl on at least two occasions or de novo hypoglycemic therapy. We compared clinical and genetic factors between patients who developed NODAT within 6 mo of transplantation (n = 118; incidence 11%) and patients without diabetes (n = 958). In multivariate analysis, NODAT significantly associated with the following characteristics: TCF7L2 polymorphism (odds ratio [OR] 1.60 per each T allele; P = 0.002), age (OR 1.03 per year; P < 0.001), body mass index at transplantation (OR 1.09 per unit; P < 0.001), tacrolimus use (OR 2.26; P < 0.001), and the occurrence of a corticoid-treated acute rejection episode (OR 2.78; P < 0.001). In summary, our data show that the TCF7L2 rs7903146 polymorphism, a known risk factor for type 2 diabetes in the general population, also associates with NODAT.