Open AccessGlomerulotubular Balance, Tubuloglomerular Feedback, and Salt Homeostasis
Author(s) -
Scott C. Thomson,
Roland C. Blantz
Publication year - 2008
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2007121326
Subject(s) - tubuloglomerular feedback , homeostasis , macula densa , balance (ability) , autoregulation , endocrinology , medicine , renal physiology , chemistry , biology , kidney , microbiology and biotechnology , neuroscience , renin–angiotensin system , blood pressure
The homeostasis of NaCl is critical to complex organisms with closed blood systems. Kidneys regulate this salt excretion by modulating the rapport between glomeruli and tubules. The tubules respond to glomeruli with glomerulotubular balance, whereas glomeruli respond to tubules through tubuloglomerular feedback. These relationships are dynamic, mysterious, and amenable to mathematical analyses. The biology underlining what is known about these interactions is observational, fragmentary, and somewhat inconclusive. Discussed here is a simple tethering of these interrelated concepts.
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