Use of the ΔAG/ΔHCO3 − Ratio in the Diagnosis of Mixed Acid-Base Disorders | Zendy

Asghar Rastegar | Zendy

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Use of the ΔAG/ΔHCO3 − Ratio in the Diagnosis of Mixed Acid-Base Disorders

Author(s) -

Asghar Rastegar

Publication year - 2007

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2006121408

Subject(s) - anion gap , bicarbonate , metabolic acidosis , acid–base imbalance , base (topology) , medicine , chemistry , gastroenterology , mathematics , mathematical analysis

When a strong acid is added to plasma, one expects a quantitative relationship between excess anion gap (DeltaAG) and bicarbonate deficit (DeltaHCO(3)(-)) with the DeltaAG/DeltaHCO(3)(-) ratio close to unity. If true, then this ratio could be used to diagnose mixed acid-base disorders in patients with metabolic acidosis. Although the mean ratio in selected patients is close to unity, this ratio also has a wide range, making its use in individual patients problematic. The ratio should therefore be used cautiously in making a diagnosis of mixed acid-base disorders.

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