Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease | Zendy

Yunxia Tao | Zendy; Iram Zafar | Zendy; Jun Kim | Zendy; Robert W. Schrier | Zendy; Charles L. Edelstein | Zendy

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Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease

Author(s) -

Yunxia Tao,

Iram Zafar,

Jun Kim,

Robert W. Schrier,

Charles L. Edelstein

Publication year - 2008

Publication title -

journal of the american society of nephrology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.451

H-Index - 279

eISSN - 1533-3450

pISSN - 1046-6673

DOI - 10.1681/asn.2006121378

Subject(s) - polycystic kidney disease , caspase , apoptosis , mediator , disease , cancer research , medicine , caspase 2 , kidney , biology , gene , caspase 3 , endocrinology , programmed cell death , genetics

Pan-caspase inhibition reduces tubular apoptosis and proliferation and slows progression of disease in a rat model of polycystic kidney disease (PKD). It is unknown, however, which specific caspases are involved in PKD progression. Because caspase-3 is a major mediator of apoptosis, its role in

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