Nodular Glomerulosclerosis in the Nondiabetic Smoker
Author(s) -
Samih H. Nasr,
Vivette D. D’Agati
Publication year - 2007
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2006121328
Subject(s) - glycation , medicine , glomerulosclerosis , oxidative stress , diabetic nephropathy , nephropathy , angiogenesis , diabetes mellitus , pathology , cardiology , proteinuria , endocrinology , kidney
Emerging evidence supports that the entity known as idiopathic nodular glomerulosclerosis is not idiopathic. A strong causative association with longstanding cigarette smoking and hypertension has been identified. Morphologically, smoking-associated nodular glomerulosclerosis closely resembles diabetic nephropathy. The potential roles of advanced glycation end products, oxidative stress, angiogenesis, and hemodynamic perturbations are explored.
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