Open AccessCritical Role of Urea in the Urine-Concentrating Mechanism
Author(s) -
Jeff M. Sands
Publication year - 2007
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2006121314
Subject(s) - urine , urea , chemistry , urine osmolality , excretion , mechanism (biology) , kidney , plasma osmolality , endocrinology , medicine , biochemistry , vasopressin , physics , quantum mechanics
The ability to produce concentrated or dilute urine allows people to vary water excretion to match water intake, thereby maintaining a nearly constant blood plasma osmolality. This is accomplished in the renal medulla through the combined actions of several transport proteins in the loops of Henle,
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom