Open AccessRenal Iron Metabolism
Author(s) -
DeLiang Zhang,
Esther G. MeyronHoltz,
Tracey A. Rouault
Publication year - 2007
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2006080908
Subject(s) - chemistry , dmt1 , ferrous , ferroportin , biochemistry , hepcidin , transporter , ferritin , transferrin , heme , intracellular , metabolism , biology , immunology , organic chemistry , iron homeostasis , inflammation , gene , enzyme
In mammalian cells, iron is required for the function of many prosthetic groups, including heme and iron-sulfur clusters. Mammals absorb dietary iron and heme across the apical mucosa of duodenal epithelial cells using a Fe2+ transporter known as divalent metal transporter 1 (DMT-1; also known as
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom