Open AccessCited1 Is a Bifunctional Transcriptional Cofactor That Regulates Early Nephronic Patterning
Author(s) -
Sergey Plisov,
Michael Tsang,
Guizhi Shi,
Scott Boyle,
Kiyoshi Yoshino,
Sally L. Dunwoodie,
Igor B. Dawid,
Toshi Shioda,
Alan O. Perantoni,
Mark P. de Caestecker
Publication year - 2005
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2004060476
Subject(s) - mesenchyme , microbiology and biotechnology , wnt signaling pathway , transcription factor , biology , morphogenesis , signal transduction , mesenchymal stem cell , genetics , gene
In a screen to identify factors that regulate the conversion of mesenchyme to epithelium during the early stages of nephrogenesis, it was found that the Smad4-interacting transcriptional cofactor, Cited1, is expressed in the condensed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiation into epithelia, and has the capacity to block UB branching and epithelial morphogenesis in cultured metanephroi. Cited1 represses Wnt/beta-catenin but activates Smad4-dependent transcription involved in TGF-beta and Bmp signaling. By modifying these pathways, Cited1 may coordinate cellular differentiation and survival signals that regulate nephronic patterning in the metanephros.