Open AccessDistribution of C cells in monkey thyroid glands as studied by the immunoperoxidase method using anti-calcitonin and anti-C-thyroglobulin antisera.
Author(s) -
Yoko Kameda
Publication year - 1983
Publication title -
archivum histologicum japonicum
Language(s) - English
Resource type - Journals
ISSN - 0004-0681
DOI - 10.1679/aohc.46.221
Subject(s) - immunoperoxidase , thyroid , thyroglobulin , calcitonin , antiserum , biology , medicine , endocrinology , epithelium , immunocytochemistry , chemistry , antibody , immunology , genetics , monoclonal antibody
The distribution of C cells in the thyroid glands of eight young adult monkeys (4 Macaca fuscata and 4 Macaca irus) was investigated by complete serial sections utilizing the immunoperoxidase method with anti-human calcitonin and anti-dog C-thyroglobulin antisera. The secretory granules of monkey C cells were strongly immunoreactive to both antisera. A markedly uneven distribution of C cells was found. The C cells were distributed in a small area restricted to the dorsomedial portion of the lobe along the longitudinal axis below the parathyroid IV, while the remaining larger portions were devoid of C cells. In the areas where the C cells were concentrated, the cells were scattered, surrounding a large portion or even the whole of the epithelium lining follicles and often forming multiple clusters among the follicles. In these places the C cells exceeded the number of follicular cells.