STIMULATION OF MILK SYNTHESIS IN THE RABBIT BY FISH PITUITARY EXTRACT | Zendy

Patrick Prunet | Zendy; L. M. Houdebine | Zendy; Claude Delouis | Zendy; Bernard Breton | Zendy

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STIMULATION OF MILK SYNTHESIS IN THE RABBIT BY FISH PITUITARY EXTRACT

Author(s) -

Patrick Prunet,

L. M. Houdebine,

Claude Delouis,

Bernard Breton

Publication year - 1979

Publication title -

journal of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.498

H-Index - 146

eISSN - 1479-6805

pISSN - 0022-0795

DOI - 10.1677/joe.0.0830393

Subject(s) - prolactin , medicine , endocrinology , trout , mammary gland , casein , lactose , organ culture , stimulation , biology , pituitary gland , explant culture , fish <actinopterygii> , chemistry , hormone , in vitro , biochemistry , fishery , cancer , breast cancer

The lactogenic properties of extracts of the pituitary glands of salmon and trout were evaluated by using the organ culture technique with rabbit mammary explants. Crude extracts and fractions obtained after chromatography on Ultrogel and selected for their capacity to compete with ovine prolactin in a rabbit mammary gland radioreceptor assay were added to the culture medium. The criteria of lactogenesis were lactose synthetase activity, casein synthesis, measurements of the concentration of casein messenger RNA and the histology of mammary glands. All these tests led to the conclusion that salmon and trout pituitary glands contain a prolactin-like principle capable of initiating milk synthesis in the rabbit mammary cell.

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