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Caspase family proteins play important roles in different stages of the apoptotic pathway. To date, however, functions of  Bombyx mori  L. (Lepidoptera: Bombycidae) caspase family genes are poorly known. This paper focuses on the morphology, mitochondrial membrane potential, and expression profiles of two novel  B. mori  caspase family genes ( ice-2  and  ice-5 ) in 3 µM hydrogen peroxide (H 2 O 2 ) damaged  B. mori  cells, which were separated from the ovary of  B. mori . In addition, comparisons were made between damage caused by H 2 O 2  and by ultraviolet (UV) irradiation. The results showed that the potential change of the mitochondrial membrane occurred at 0.5 h after H 2 O 2  stimulation, which was sooner than occurred in the UV treated model where the obvious decrease appeared at 6 h after stimulation. In addition, the total change in the potential of the mitochondrial membrane in H 2 O 2  treated  B. mori  cells was larger than with UV treated cells during the whole process. Analysis of fluorescent quantitative real-time PCR demonstrated that  ice-2  and  ice-5  might be involved in both H 2 O 2  and UV-induced apoptosis in  B. mori  cells. Notably, after exposure to H 2 O 2 , the expression patterns of  ice-5  were remarkably higher than those of  ice-2 , while the result was the opposite after exposure to UV irradiation. The data indicate that apoptosis induced by H 2 O 2  was directly related to the mitochondrial pathway. The two isoforms of  B. mori ice  may play different roles in the mitochondrion associated apoptotic pathway in  B. mori  cells, and the apoptotic pathway in H 2 O 2  induced  B. mori  cells is different from the UV induced apoptotic pathway.

Synchronized Expression of Two Caspase Family Genes,ice-2andice-5, in Hydrogen Peroxide-Induced Cells of the Silkworm,Bombyx mori