Open AccessIntracranial Response to Anti‐Programmed Death 1 Therapy in a Patient with Metastatic Non‐Small Cell Lung Cancer with Leptomeningeal Carcinomatosis
Author(s) -
Kamath Suneel D.,
Kumthekar Priya U.,
Kruser Tim J.,
Mohindra Nisha A.
Publication year - 2018
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2018-0022
Subject(s) - medicine , radiosurgery , lung cancer , meningeal carcinomatosis , adenocarcinoma , parenchyma , brain metastasis , lung , central nervous system , metastasis , pathology , cancer , oncology , radiology , radiation therapy , cerebrospinal fluid
Central nervous system metastasis in non‐small cell lung cancer remains a therapeutic challenge and confers a poor prognosis. Here we describe a patient with lung adenocarcinoma, parenchymal brain metastases, and leptomeningeal carcinomatosis who demonstrated a sustained response to programmed death 1 inhibition combined with stereotactic radiosurgery.