Open AccessDiazoxide for Lowering Insulin Levels in Breast Cancer Patients
Author(s) -
Fink Michael K.,
Klement Rainer J.
Publication year - 2017
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2016-0402
Subject(s) - diazoxide , medicine , benzothiadiazine , insulin , breast cancer , cancer , endocrinology , pharmacology , chemistry , organic chemistry
Diazoxide is a nondiuretic benzothiadiazine that produces hyperglycemia by lowering insulin levels through activation of ATP‐sensitive K1‐channels and stimulating insulin degradation in the lysosomal system. Its effect on cancer growth is discussed.