Open AccessExceptional Responders Inspire Change: Lessons for Drug Development From the Bedside to the Bench and Back
Author(s) -
Chau Nicole G.,
Lorch Jochen H.
Publication year - 2015
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2014-0476
Subject(s) - medicine , bench to bedside , drug development , profiling (computer programming) , precision medicine , intensive care medicine , disease , bioinformatics , drug , medical physics , pharmacology , pathology , computer science , biology , operating system
Targeted therapies have changed the landscape of cancer treatment, although they fail too many patients with advanced cancer. Still, insight gained from an exceptional responder has the power to identify new biomarkers of sensitivity that can unlock subsets of patients across anatomic disease sites who may also derive benefit and facilitate development of novel therapeutic strategies that may overcome resistance. The use of large‐scale genomic profiling is a promising first step.