The Untimely Passing of a Great Man: Eddie Reed, M.D., 1953–2014

On May 28, 2014, two pillars of the American intellectual community died. The first was Maya Angelou, the noted poet and actress, who left a permanent imprint in the Arts and Letters scene, ascending in a remarkable career from a most humble childhood to the highest echelons of literary achievement. On the same day, the cancer research community lost one of its brightest stars with the passing of Eddie Reed, M.D. His story, although less well-known, is equally remarkable and a cause for both sorrow and celebration. Eddie Reed was born in Hughes, Arkansas, one of 18 children raised on a farm in the Mississippi Delta near Memphis, Tennessee. His early years were spent attending rural schools, playing the drums, and working on the farm, cutting cotton and tending the okra plants. For his parents, education was everything, and each child was expected to excel in school and attend college. The kids got the message. The Reed children became lawyers, doctors, scientists, and prominent agronomists. Eddie Reed chose medicine as his callingwhile a college student at Philander Smith College in Little Rock, Arkansas, and in the summer of his sophomore year, 1972, he came to theNational Cancer Institute towork in my laboratory. For the first fewweeks, 18-year-old Eddie from rural Arkansas said very little. His silence at first caused me concern. Was I failing as a teacher and mentor? Over the summer, it was apparent that hewas taking it all in, getting his bearings, listening attentively, and learning hiswayaround the laboratory. He was a model student! We became friends. It became clear that he was absorbing everything we offered, including enzyme kinetics, drug metabolism, and chromatography. He had outstanding talent at the bench, wherehedidhisexperimentscarefullyandwithanuncommon focus on detail. He loved the complexity and logic of cancer therapeutics and the challenge of understanding how these drugs worked, and he came back for additional summer sessions throughout college. With my encouragement he set his sights high andwas accepted toYaleMedical School,where he chose to do his thesis on allopurinol pharmacokinetics back at NCI. After completing his residency at Stanford, to our great joy, he officially joined NCI as a medical oncology fellow in the “Class of 1981.” The early 1980s brought an outstanding collection of fellows to train at that venerable institution. Neal Rosen, Ed Sausville, Nancy Davidson, Carmen Allegra, Chris Berg, Gino Bottino, Ron Steis, Jeff Clark, Marcia Browne, and Steve Averbuch were among his colleagues in the fellowship during those years. Eddie worked as a fellow with Miriam Poirier, an expert on DNA repair in the carcinogenesis laboratories at NCI and became a fixture in the pharmacology group there. For the next 19 years, he followed his passion for understanding the role of DNA repair in determining response and toxicity related to theplatinumdrugs, rising to theposition of Chief of the Clinical Pharmacology Branch. Eddie’sworkwas among the first to implicate DNAexcision repair as adeterminant of response, andheoffered the further insight that NER capacity was shared by host and tumor as a function of genetic polymorphism, a concept that now rests on solid ground. He became an authority on the treatment of ovarian cancer, filed patents for paclitaxel regimens in that disease, and regularly contributed to many of the primary textbooks in the cancer field. He was an honest reviewer and critic: I remember, “Bruce, Bruce, wait a minute. You don’t really understand the point.” Very few ex-fellows were that bluntwithme, butmoreoften thannot, hewas right. In all, 300 peer-reviewed publications, many book chapters, and editorials testify to his long and productive career in the laboratory and in the clinic. His second passion was ensuring access to cancer care for underservedcommunities.During the last13yearsofhiswork, he had the opportunity to lead programs deeply immersed in issues of equity and access to care. In 2001 he became the Director of the Mary Babb Randolph Cancer Center at the UniversityofWestVirginia inMorgantown,wherehe recruited a talented staff of young oncologists. In 2005, he accepted the prominent position of Director of the Division of Cancer Prevention and Control at the Centers for Communicable Disease in Atlanta, a national program responsible for the support of many projects related to cancer screening and prevention in minority and underserved communities. He fought for a continuation of these programs during a period of retrenchment and left the CDC a frustrated man. In 2008, he becametheClinicalDirectorof theMitchell CancerCenterat the University of South Alabama, joining his longtimeNCI colleague and friend,Michael Boyd. All thewhile, he continued his clinical work on ovarian cancer, his participation in national and internationalscientificmeetingsandnationalcooperativegroup activities, committee service with the National Toxicology Center, the American Association for Cancer Research, and the FoodandDrugAdministration, andofcoursehis own laboratory work, most recently investigating the regulation of DNA repair by the Hedgehog pathway. Eddie Reed’s personal life was centered around his son Edward, a talented and handsome young man who died tragicallyatage23whenhiscarwashitbyan intoxicateddriver. Through these difficult times, he had the constant love and supportofhiswifeof20years,MeenakshiReed,alsoascientist,