Open AccessSpontaneous Regression of Crizotinib‐Associated Complex Renal Cysts During Continuous Crizotinib Treatment
Author(s) -
Klempner Samuel J.,
Aubin Golnaz,
Dash Atreya,
Ou SaiHong Ignatius
Publication year - 2014
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2014-0216
Subject(s) - crizotinib , medicine , asymptomatic , context (archaeology) , natural history , lung cancer , oncology , paleontology , biology , malignant pleural effusion
This study describes the development and regression of crizotinib‐associated complex renal cysts (CACRCs) in a female patient with ALK ‐positive advanced non‐small cell lung cancer with an ongoing complete response while on continuous crizotinib treatment. The clinical context of crizotinib use requires frequent imaging studies; therefore observation is probably the best approach to CACRC management in asymptomatic patients. The natural history of CACRCs remains unknown, and large‐scale longitudinal follow‐up studies of these cysts are eagerly awaited.