Open AccessQuality of Life in the Trastuzumab for Gastric Cancer Trial
Author(s) -
Satoh Taroh,
Bang YungJue,
Gotovkin Evgeny A.,
Hamamoto Yasuo,
Kang YoonKoo,
Moiseyenko Vladimir M.,
Ohtsu Atsushi,
Van Cutsem Eric,
AlSakaff Nedal,
Urspruch Alexa,
Hill Julie,
Weber Harald A.,
Chung HyunCheol
Publication year - 2014
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2014-0058
Subject(s) - medicine , trastuzumab , capecitabine , chemotherapy , cancer , oncology , quality of life (healthcare) , clinical trial , gastroenterology , surgery , breast cancer , colorectal cancer , nursing
Background. The Trastuzumab for Gastric Cancer phase III trial demonstrated that combining trastuzumab with chemotherapy significantly improved overall survival compared with chemotherapy alone in HER2‐positive advanced gastric or gastroesophageal junction cancer. We report health‐related quality of life (HRQoL) and quality‐adjusted time without symptoms of disease or toxicity (Q‐TWiST) results from this trial. Patients and Methods. Patients were randomized to receive six cycles of chemotherapy given every 3 weeks (capecitabine or fluorouracil, plus cisplatin) either alone or combined with administration of trastuzumab every 3 weeks until disease progression. At each clinical visit, HRQoL was assessed using two European Organization for Research and Treatment of Cancer quality of life questionnaires, QLQ‐C30 and QLQ‐STO22. Q‐TWiST methodology was applied retrospectively using the clinical data and utility coefficients. Results. Trastuzumab plus chemotherapy prolonged time to 10% definitive deterioration in all QLQ‐C30 and QLQ‐STO22 scores, including QLQ‐C30 global health status versus chemotherapy alone, from 6.4 months to 10.2 months. In addition, trastuzumab plus chemotherapy extended Q‐TWiST by 2.42 months compared with chemotherapy alone. Conclusion. Compared with chemotherapy alone, trastuzumab plus chemotherapy prolongs time to deterioration of HRQoL and increases quality‐adjusted survival in patients with HER2‐positive gastric or gastroesophageal junction cancer.