Open AccessVisceral Fat Area as a New Independent Predictive Factor of Survival in Patients with Metastatic Renal Cell Carcinoma Treated with Antiangiogenic Agents
Author(s) -
Ladoire Sylvain,
Bonnetain Franck,
Gauthier Mélanie,
Zanetta Sylvie,
Petit Jean Michel,
Guiu Séverine,
Kermarrec Isabelle,
Mourey Eric,
Michel Frederic,
Krause Denis,
Hillon Patrick,
Cormier Luc,
Ghiringhelli François,
Guiu Boris
Publication year - 2011
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2010-0227
Subject(s) - medicine , sunitinib , sorafenib , renal cell carcinoma , bevacizumab , oncology , population , biomarker , multivariate analysis , body mass index , angiogenesis , adipose tissue , vascular endothelial growth factor , hepatocellular carcinoma , vegf receptors , chemotherapy , biochemistry , chemistry , environmental health
Purpose. A better identification of patients who are more likely to benefit from vascular endothelial growth factor–targeted therapy is warranted in metastatic renal cell carcinoma (mRCC). As adipose tissue releases angiogenic factors, we determined whether parameters such as visceral fat area (VFA) were associated with outcome in these patients. Experimental Design. In 113 patients with mRCC who received antiangiogenic agents (bevacizumab, sunitinib, or sorafenib) ( n = 64) or cytokines ( n = 49) as first‐line treatment, we used computed tomography to measure VFA and subcutaneous fat area (SFA). We evaluated associations linking body mass index (BMI), SFA, and VFA to time to progression (TTP) and overall survival (OS). Results. High SFA and VFA values were significantly associated with shorter TTP and OS. By multivariate analysis, high VFA was independently associated with shorter TTP and OS. These results were internally validated using bootstrap analysis. By contrast, VFA was not associated with survival in the cytokine group. In the whole population, interaction between VFA and treatment group was significant for TTP and OS, thereby confirming the results. Conclusion. Our study provides the first evidence that high VFA could be a predictive biomarker from shorter survival in patients given first‐line antiangiogenic agents for mRCC.