Open AccessNonmyeloablative Allogeneic Stem Cell Transplantation for Nasopharyngeal Carcinoma
Author(s) -
Chia Whay K.,
Wang Who W.,
Lim Wan T.,
Tai Wai M.,
Sun Li,
Thng Choon H.,
Soe Yatanar,
Yap Swee P.,
Tan Eng H.,
Toh Han C.
Publication year - 2010
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2010-0204
Subject(s) - medicine , nasopharyngeal carcinoma , transplantation , stem cell , oncology , radiation therapy , genetics , biology
We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow—an effect likely achieved via a graft‐versus‐tumor response. Although NST has been explored previously in solid tumors, such as renal cell carcinoma and breast cancer, it has not been widely explored in nasopharyngeal carcinoma. We also present data from a flow cytometric immune analysis and cytokine enzyme‐linked immunosorbent assay analysis in the pre‐ and post‐NST period.