Open AccessPredicting Response to EGFR Inhibitors in Metastatic Colorectal Cancer: Current Practice and Future Directions
Author(s) -
Shankaran Veena,
Obel Jennifer,
Benson Al B.
Publication year - 2010
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2009-0221
Subject(s) - kras , medicine , panitumumab , colorectal cancer , cetuximab , tensin , oncology , predictive marker , clinical trial , epidermal growth factor receptor , pten , targeted therapy , egfr inhibitors , cancer , pi3k/akt/mtor pathway , bioinformatics , cancer research , signal transduction , biology , genetics
The identification of KRAS mutational status as a predictive marker of response to antibodies against the epidermal growth factor receptor (EGFR) has been one of the most significant and practice‐changing recent advances in colorectal cancer research. Recently, data suggesting a potential role for other markers (including BRAF mutations, loss of phosphatase and tensin homologue deleted on chromosome ten expression, and phosphatidylinositol‐3‐kinase–AKT pathway mutations) in predicting response to anti‐EGFR therapy have emerged. Ongoing clinical trials and correlative analyses are essential to definitively identify predictive markers and develop therapeutic strategies for patients who may not derive benefit from anti‐EGFR therapy. This article reviews recent clinical trials supporting the predictive role of KRAS , recent changes to clinical guidelines and pharmaceutical labeling, investigational predictive molecular markers, and newer clinical trials targeting patients with mutated KRAS .