Open AccessHigh Expression of Macrophage Colony‐Stimulating Factor‐1 Receptor in Peritumoral Liver Tissue Is Associated with Poor Outcome in Hepatocellular Carcinoma After Curative Resection
Author(s) -
Jia JinBin,
Wang WenQuan,
Sun HuiChuan,
Zhu XiaoDong,
Liu Liang,
Zhuang PengYuan,
Zhang JuBo,
Zhang Wei,
Xu HuaXiang,
Kong LingQun,
Lu Lu,
Wu WeiZhong,
Wang Lu,
Tang ZhaoYou
Publication year - 2010
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2009-0170
Subject(s) - medicine , hepatocellular carcinoma , tissue microarray , immunohistochemistry , pathology , hepatectomy , intrahepatic cholangiocarcinoma , metastasis , oncology , gastroenterology , cancer , resection , surgery
Background. Macrophage colony‐stimulating factor 1 receptor (CSF‐1R) expression in hepatocellular carcinoma (HCC) and its prognostic values are unclear. This study evaluated the prognostic values of the intratumoral and peritumoral expression of CSF‐1R in HCC patients after curative resection. Methods. Tissue microarrays containing material from cohort 1 (105 patients) and cohort 2 (32 patients) were constructed. Immunohistochemistry was performed and prognostic values of these and other clinicopathological data were evaluated. The CSF‐1R mRNA level was assessed by quantitative real‐time polymerase chain reaction in cohort 3 (52 patients). Results. Both the CSF‐1R density and its mRNA level were significantly higher in peritumoral liver tissue than in the corresponding tumor tissue. CSF‐1R was distributed in a gradient in the long‐distance peritumoral tissue microarray, with its density decreasing as the distance from the tumor margin increased. High peritumoral CSF‐1R was significantly associated with more intrahepatic metastases and poorer survival. Peritumoral CSF‐1R was an independent prognostic factor for both overall survival and time to recurrence and affected the incidence of early recurrence. However, intratumoral CSF‐1R did not correlate with any clinicopathological feature. Peritumoral CSF‐1R was also associated with both overall survival and time to recurrence in a subgroup with small HCCs (≤5 cm). Conclusions. Peritumoral CSF‐1R is associated with intrahepatic metastasis, tumor recurrence, and patient survival after hepatectomy, highlighting the critical role of the peritumoral liver milieu in HCC progression. CSF‐1R may become a potential therapeutic target for postoperative adjuvant treatment.