Open AccessEpidermal Growth Factor Receptor Expression and Mutational Analysis in Synovial Sarcomas and Malignant Peripheral Nerve Sheath Tumors
Author(s) -
Tawbi Hussein,
Thomas Dafydd,
Lucas David R.,
Biermann J. Sybil,
Schuetze Scott M.,
Hart Anita L.,
Chugh Rashmi,
Baker Laurence H.
Publication year - 2008
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2007-0166
Subject(s) - epidermal growth factor receptor , medicine , malignant peripheral nerve sheath tumor , immunohistochemistry , synovial sarcoma , pathology , tissue microarray , neurofibromatosis , cancer research , tyrosine kinase , cancer , sarcoma , receptor
L earning O bjectives After completing this course, the reader will be able to: Discuss the significance of deletions and mutations of the EGFR gene in cancer cell growth and survival. Describe the significance of the role of EGFR in malignant peripheral nerve sheath tumors, especially those associated with neurofibromatosis 1. Discuss the significance of why small molecule inhibitor therapy has been ineffectual in synovial sarcomas and malignant peripheral nerve sheath tumors.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com