Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR | Zendy

Ratna K. Vadlamudi | Zendy; Rakesh Kumar | Zendy

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Functional and biological properties of the nuclear receptor coregulator PELP1/MNAR

Author(s) -

Ratna K. Vadlamudi,

Rakesh Kumar

Publication year - 2007

Publication title -

nuclear receptor signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 33

ISSN - 1550-7629

DOI - 10.1621/nrs.05004

Subject(s) - nuclear receptor , biology , estrogen receptor , receptor , scaffold protein , nuclear localization sequence , computational biology , cancer research , microbiology and biotechnology , signal transduction , breast cancer , cancer , genetics , gene , transcription factor

Proline-, glutamic acid-, and leucine-rich protein (PELP)1, also known as modulator of nongenomic actions of the estrogen receptor (MNAR), is a novel nuclear receptor coregulator with a multitude of functions. PELP1/MNAR serves as a scaffolding protein that couples various signaling complexes with nuclear receptors and participates in genomic and nongenomic functions. Recent data suggest that PELP1/MNAR expression is deregulated in several cancers, including breast, endometrial, prostate, and ovarian cancer, and that PELP1/MNAR interacts with several oncogenes. In this review, we summarize the emerging biological properties and functions of PELP1/MNAR.

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