A Tale of two Estrogen Receptors (ERs): How Differential ER-Estrogen Responsive Element Interactions Contribute to Subtype-Specific Transcriptional Responses | Zendy

Jing Huang | Zendy; Xiaodong Li | Zendy; Tao Qiao | Zendy; Robert A. Bambara | Zendy; Russell Hilf | Zendy; Mesut Muyan | Zendy

Open Access

A Tale of two Estrogen Receptors (ERs): How Differential ER-Estrogen Responsive Element Interactions Contribute to Subtype-Specific Transcriptional Responses

Author(s) -

Jing Huang,

Xiaodong Li,

Tao Qiao,

Robert A. Bambara,

Russell Hilf,

Mesut Muyan

Publication year - 2006

Publication title -

nuclear receptor signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 33

ISSN - 1550-7629

DOI - 10.1621/nrs.04015

Subject(s) - transactivation , estrogen receptor , estrogen receptor beta , estrogen , biology , perspective (graphical) , nuclear receptor , estrogen receptor alpha , computational biology , cancer research , microbiology and biotechnology , bioinformatics , transcription factor , genetics , computer science , gene , cancer , breast cancer , artificial intelligence

The interaction of ERalpha and ERbeta with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERbeta is a weaker transactivator than E2-ERalpha. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional responses.

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