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The interaction of ERalpha and ERbeta with ERE constitutes the initial step in the canonical nuclear E2 signaling in which E2-ERbeta is a weaker transactivator than E2-ERalpha. This perspective summarizes recent findings to discuss potential mechanisms that contribute to ER subtype-specific transcriptional responses.

nuclear receptor signaling

A Tale of two Estrogen Receptors (ERs): How Differential ER-Estrogen Responsive Element Interactions Contribute to Subtype-Specific Transcriptional Responses