RNAi technology and its use in studying the function of nuclear receptors and coregulators | Zendy

Haijun Zhou | Zendy; Sophia Y. Tsai | Zendy; MingJer Tsai | Zendy

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RNAi technology and its use in studying the function of nuclear receptors and coregulators

Author(s) -

Haijun Zhou,

Sophia Y. Tsai,

MingJer Tsai

Publication year - 2003

Publication title -

nuclear receptor signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 33

ISSN - 1550-7629

DOI - 10.1621/nrs.01008

Subject(s) - rna interference , biology , rna silencing , gene silencing , small interfering rna , genetics , computational biology , rna induced silencing complex , gene , trans acting sirna , microbiology and biotechnology , rna

Until just a few years ago, RNA interference (RNAi) technology was restricted to the research fields of plants, C. elegans or Drosophila. The discovery of gene silencing by in vitro synthesized double-stranded RNA (dsRNA) in mammalian cells has made the use of RNAi possible in nearly the entire life science kingdom. DNA vectors delivering small interfering RNA (siRNA) directed by polymerase III or polymerase II promoters to persistently inhibit target genes expression have extended this technology to study in vivo function of these genes. Recently, RNAi has been used as a powerful tool in the functional analysis of nuclear receptors and their coregulators. This short review will cover studies in this area.

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