Expression and Function Profiling of Orphan Nuclear Receptors using Bacterial Artificial Chromosome (BAC) Transgenesis | Zendy

Éric Némoz-Gaillard | Zendy; MingJer Tsai | Zendy; Sophia Y. Tsai | Zendy

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Expression and Function Profiling of Orphan Nuclear Receptors using Bacterial Artificial Chromosome (BAC) Transgenesis

Author(s) -

Éric Némoz-Gaillard,

MingJer Tsai,

Sophia Y. Tsai

Publication year - 2003

Publication title -

nuclear receptor signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 33

ISSN - 1550-7629

DOI - 10.1621/nrs.01005

Subject(s) - bacterial artificial chromosome , nuclear receptor , biology , orphan receptor , computational biology , transgenesis , receptor , neuron derived orphan receptor 1 , genetics , bioinformatics , microbiology and biotechnology , genome , gene , transcription factor , embryogenesis , reproductive biology

The long term goal of the Nuclear Receptor Signaling Atlas (NURSA) resides in unraveling the physiological and pathological functions of nuclear receptors (NRs) at the molecular, biochemical and cellular levels. This multi-oriented task requires complementary approaches in order to determine the specific function(s) and precise expression and receptor activity patterns for each individual conventional or orphan receptor. To attain this objective, we have chose to turn to technologies recently made available to engineer bacterial artificial chromosomes (BACs).

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