Nuclear receptor corepressors | Zendy

Mitchell A. Lazar | Zendy

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Nuclear receptor corepressors

Author(s) -

Mitchell A. Lazar

Publication year - 2003

Publication title -

nuclear receptor signaling

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.434

H-Index - 33

ISSN - 1550-7629

DOI - 10.1621/nrs.01001

Subject(s) - corepressor , psychological repression , nuclear receptor , heterologous , function (biology) , biology , computational biology , microbiology and biotechnology , genetics , transcription factor , gene , gene expression

The ability of NR LBDs to transfer repression function to a heterologous DNA binding domain, and the cross-squelching of repression by untethered LBDs, has suggested that repression is mediated by interactions with putative cellular corepressor proteins. The yeast-two hybrid screen for protein interactors has proven to be the key to the isolation and characterization of corepressors. This short review will focus on N-CoR and SMRT.

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