Open AccessBlocking effect of tripelennamine on histamine- induced positive chronotropic and inotropic responses of the dog atrium.
Author(s) -
Shigetoshi Chiba
Publication year - 1976
Publication title -
tohoku journal of experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.514
H-Index - 59
eISSN - 1349-3329
pISSN - 0040-8727
DOI - 10.1620/tjem.120.299
Subject(s) - chronotropic , histamine , inotrope , propranolol , metiamide , medicine , cimetidine , chemistry , histamine h2 receptor , endocrinology , histamine receptor , pharmacology , receptor , heart rate , antagonist , blood pressure
The effects of histamine on inotropic and chronotropic activity were investigated in isolated canine atrium preparations which were suspended in a bath and perfused with arterial blood from a carotid artery of heparinized support dog. Histamine administered into the cannulated sinus node artery in a dose range of 0.3-100 mug produced dose-related positive chronotropic and inotropic effects. The positive responses to histamine were not suppressed by treatment with propranolol in doses which blocked responses to norepinephrine, but these were significantly suppressed by a histamine H1 receptor blocking agent, tripelennamine. On the other hand, these histamine-induced effects were not modified by a histamine H2 receptor blocking agent, burimamide. From these results, it is assumed that positive chronotropic and inotropic effect of histamine may be mediated by histamine H1 receptors in the dog heart.