Antibody Response Against Anopheles albimanus (Diptera: Culicidae) Salivary Protein as a Measure of Mosquito Bite Exposure in Haiti | Zendy

Berlin Londoño-Rentería | Zendy; Thomas P. Eisele | Zendy; Joseph Keating | Zendy; Mark A. James | Zendy; Dawn M. Wesson | Zendy

Open Access

Antibody Response Against Anopheles albimanus (Diptera: Culicidae) Salivary Protein as a Measure of Mosquito Bite Exposure in Haiti

Author(s) -

Berlin Londoño-Rentería,

Thomas P. Eisele,

Joseph Keating,

Mark A. James,

Dawn M. Wesson

Publication year - 2010

Publication title -

journal of medical entomology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.866

H-Index - 99

eISSN - 1938-2928

pISSN - 0022-2585

DOI - 10.1603/me09240

Subject(s) - anopheles albimanus , malaria , biology , saliva , antibody , vector (molecular biology) , immunology , anopheles , plasmodium vivax , insect bites and stings , virology , plasmodium falciparum , recombinant dna , biochemistry , gene

Antibodies against arthropod saliva have shown to be a good marker of bite exposure. Because Anopheles albimanus Wiedemann (Diptera: Culicidae) is the principal malaria vector in Haiti, we evaluated the immune response against salivary gland extract (SGE) of this species in malaria-positive and malaria-negative subjects from this country. The results showed that the level of anti-SGE immunoglobulin (Ig)G antibodies was higher in patients with clinical malaria than those in malaria uninfected people living in the same region. In addition, a significant positive correlation between the level of anti-An. albimanus IgG and IgM antibody levels was observed. These results suggest that antibodies against An. albimanus saliva, especially IgG, are useful markers of mosquito bite exposure in Haiti.

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