Immunoprofiles of 11 Biomarkers Using Tissue Microarrays Identify Prognostic Subgroups in Colorectal Cancer | Zendy

Thomas Knösel | Zendy; Anna Emde | Zendy; Karsten Schlüns | Zendy; Chen Yuan | Zendy; Karsten Jürchott | Zendy; Matthias Krause | Zendy; Manfred Dietel | Zendy; Iver Petersen | Zendy

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Immunoprofiles of 11 Biomarkers Using Tissue Microarrays Identify Prognostic Subgroups in Colorectal Cancer

Author(s) -

Thomas Knösel,

Anna Emde,

Karsten Schlüns,

Chen Yuan,

Karsten Jürchott,

Matthias Krause,

Manfred Dietel,

Iver Petersen

Publication year - 2005

Publication title -

neoplasia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.52

H-Index - 129

eISSN - 1522-8002

pISSN - 1476-5586

DOI - 10.1593/neo.05178

Subject(s) - colorectal cancer , tissue microarray , dna microarray , cancer , oncology , medicine , biology , pathology , computational biology , bioinformatics , cancer research , genetics , gene expression , gene

Genomewide expression profiling has identified a number of genes expressed at higher levels in colorectal cancer (CRC) than in normal tissues. Our objectives in this study were: 1) to test whether genes were also distinct on the protein level; 2) to evaluate these biomarkers in a series of well-characterized CRCs; and 3) to apply hierarchical cluster analysis to the immunohistochemical data.

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