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Pemberian sedasi dan analgesi yang efektif, efisien, aman, mudah didapat, dan juga murah diperlukan untuk mengurangi nyeri serta kecemasan selama kuretase.  Tujuan penelitian ini adalah mengetahui perbedaan kebutuhan propofol dan lama bangun antara propofol-ketamin dan propofol-fentanil pada pasien yang dilakukan kuretase. Dilakukan penelitian uji klinis acak tersamar tunggal pada 60 pasien yang menjalani kuretase di Rumah Sakit Dr. Hasan Sadikin Bandung periode September–November 2014.  Pasien dibagi dalam dua kelompok, yaitu propofol-ketamin (PK) dan propofol-fentanil (PF). Data hasil penelitian  untuk tekanan darah, laju nadi, laju napas, saturasi oksigen, dan skor bispectral index (BIS) dianalisis dengan uji-t dan Uji Mann-Whitney. Hasil penelitian menunjukkan kebutuhan propofol berbeda secara sangat bermakna (p<0,001), pada kelompok PK terdapat 4/30 subjek yang mendapatkan tambahan propofol, sedangkan pada kelompok PF sebanyak 14/30 subjek. Lama bangun pada kelompok PK adalah 25,75±2,47 menit, sedangkan pada kelompok PF adalah 21,08±2,52. Secara statistik hasil tersebut berbeda secara sangat bermakna (p<0,001). Simpulan, kebutuhan propofol pada kelompok PK lebih sedikit dibanding dengan kelompok PF dan lama bangun pada kelompok PK lebih lama dibanding dengan kelompok PF. Kata kunci: Bispectral index, kebutuhan propofol, kuretase, lama bangun Comparison of Propofol Requirements and Emergence Time between Propofol-Ketamine and Propofol-Fentanyl Combinations in Patients Undergoing Curretage using Bispectral Index (BIS) Monitoring Adequate administration of safe, easy-to-obtain, and constantly available sedatives and analgesia, is needed for pain reduction throughout curettage procedures. The goal of this study was to examine differences in propofol requirements and emergence time between propofol-ketamine and propofol-fentanyl combinations in patients undergoing curettage. A single-blind randomized controlled trial study was performed on 60 patients who underwent curettage procedures. The patients were divided into two groups: propofol-ketamine (PK) and propofol-fentanyl (PF). Blood pressure, pulse rate, respiration rate, and oxygen saturation and BIS data were analysed using a t-test and Mann-Whitney test. This study showed that propofol requirements differ significantly (p<0.001) between the two groups where in PK group where 4/30 subjects received additional propofol, compared to PF group 14/30 subjects received additional propofol. The wake up time for PK group was 25.75±2.47 minutes compared to 21.08±2.52 minutes for the PF group. The difference was statistically significant (p<0.001). The conclusions of this study are propofol requirements for PK group is less compared to PF group and the emergence time for PK group is longer compared to PF group. Key words: Bispectral index, curettage, emergence time, propofol requirements DOI :  10.15851/jap.v3n3.611

jurnal anestesi perioperatif

Perbandingan Kebutuhan Propofol dan Lama Bangun antara Kombinasi Propofol-Ketamin dan Propofol-Fentanil pada Pasien yang Dilakukan Kuretase yang Diukur dengan Bispectral Index (BIS)