Liver biopsy to the aid in diagnosis of pediatric hemophagocytic lymphohistiocytosis: A case report | Zendy

K. R. Chatura | Zendy; Bhargavi Mohan | Zendy

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Liver biopsy to the aid in diagnosis of pediatric hemophagocytic lymphohistiocytosis: A case report

Author(s) -

K. R. Chatura,

Bhargavi Mohan

Publication year - 2017

Publication title -

journal of medicine radiology pathology and surgery

Language(s) - English

Resource type - Journals

ISSN - 2395-2075

DOI - 10.15713/ins.jmrps.93

Subject(s) - hemophagocytic lymphohistiocytosis , medicine , liver biopsy , biopsy , hemophagocytosis , intensive care medicine , pediatrics , radiology , pathology , bone marrow , disease , pancytopenia

Hemophagocytic lymphohistiocytosis (HLH) is a result of uncontrolled macrophage activation with prominent phagocytosis of platelets, erythrocytes, and lymphocytes and hematopoietic precursors. Attempt should be made to establish or rule out HLH in patients presenting with fever, multisystem inflammation, and varying degrees of unexplained pancytopenia. Owing to the guarded prognosis associated with HLH, differentiation from other causes of pediatric liver disease is critical and is a diagnostic challenge.

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