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Aim of the Study: To statistically demonstrate the enhanced specificity and sensitivity of Biosensors over other comparative investigative procedures for detection of oral precancer over a decade. Materials and Methods: Study sample included a review of research articles, based on databases from the Cochrane collaboration having a definite randomized control trial, on various investigative procedures for oral pre-cancer lesions and conditions and oral cancer itself over the past decade. This included literature on toluidine blue, Lugol’s iodine, Vizilite, Velscope, Colposcopy, and Biosensors The mainstay of the intended study. The literature was assessed, analyzed, and studied; the comparison was made based on the various P values between various techniques on one side and biosensors on the other in terms of sensitivity and specificity. A meta-analysis of all the modalities including the above-mentioned parameters was carried out and advantages and disadvantages documented and compared with those of Biosensors to demonstrate the title of the study. Result: Compared to the 100% sensitivity and specificity of biosensors, the sensitivity, and specificity of vital staining techniques were found to be, respectively, 95% and 81%, whereas the sensitivity and specificity of visual aids were found to be, respectively, 86% and 78%. Conclusion: Biosensors definitely came up as the best diagnostic aids and investigative procedures at hand compared to all others existing or tried so far.

Biosensors: The advanced molecular probes - A meta-analysis over a decade