Effect of melatonin on osseointegration of immediate loading implant supported mandibular over denture: Randomized clinical trail

Background: In the recent years, immediate loading of implant is very demanding to shorten the rehabilitation time. Some authors claimed that Melatonin induces bone formation, increase bone density, and bone implant contact. The aim of this study is to assess the eff ect of local melatonin administration on bone density around immediateloaded implant supported over denture. Materials and Methods: Eight completely edentulous patients were selected. The Patient’s age ranged between 55 to 65 years old. The study was split-mouth technique, each patient served as his own control, the study group (topical application of melatonin in the implant side), the control group (no melatonin in the other implant side of the same patients).Immediately after the implant placement, implant stability test was performed using the Osstell Monitor, and Digora system was used for assessing the bone density changes. The Radiographic bone density measurements, implant stability assessment, and implant survival were performed at time of loading then at 3, 6 and 12 months after loading. Results: A high statistically signifi cant diff erence in bone density and implant stability in the immediately loaded implants with local melatonin application (P = 0.001). Conclusion: The local melatonin administration increase bone density and improve the osseointegration processes around immediate-loaded implant supported over dentures.