Evaluation of Macrocytosis in a Routine Haemogram

7 accompanied by other abnormalities. Macrocytosis by itself does not cause any symptoms or complications. However, its presence can give clue regarding the presence of an underlying disease, thereby helping in early diagnosis and treatment. Hence, presence of macrocytosis needs clinical and laboratory assessment to Abstract Macrocytosis is a common laboratory abnormality seen in various clinical settings. 4-9 The reported prevalence across various studies range from 1.7-4 %. Macrocytosis precedes anaemia and can occur without anaemia. Mild macrocytosis with Mean Corpuscular Volume (MCV) between 100-110 femtolitres(fl) is more common than 8 severe macrocytosis and can remain unexplained even after extensive evaluation. Macrocytic anaemia is classified into two groups-Megaloblastic and nonmegaloblastic anaemia depending upon the morphological and biochemical finding. We conducted this study to find out the underlying aetiologies in patients with macrocytosis. We also evaluated various clinical, biochemical and haematological features in these patients so as to find out the difference between megaloblastic macrocytic and non-megaloblastic macrocytic anaemia. This has important clinical implications as assays of serum B and folate levels may not be available in all the 12