THERAPEUTIC POTENTIAL OF MODERN PROBIOTICS

Vladimirsky Moscow Regional Clinical Research Institute, Russian Federation Therapeutic potential of modern probiotics Author affiliation: Ursova Nataliya Igorevna, PhD, professor, chief research scientist at the pediatric department of the Vladimirsky Moscow Regional Clinical Research Institute (MRCRI) Address: building 5, 61/2, Shchepkina Str., Moscow, 129110, tel.: +7 (495) 681-25-98, e-mail: ursovan@mail.ru Article received: 05.11.2012 accepted for publication: 24.03.2013 This discussion article adduces a short review of clinical studies where the use of probiotics has shown the best results. The issues of whether probiotics are capable of having a protective effect on the intestinal barrier, an antagonist effect – on opportunistic microbes and a stimulatory effect – on the immune system, are discussed. The best studied production species and strains forming probiotic drugs are observed. The differences between monostrain and multispecies probiotics are given. The reasonability of using combined drugs with combinational additive or synergetic strain-specific effects is explained.