Role of microbiota correction in complex treatment of pregnant women with herpesvirus infection

Relevance. Dysbiotic disorders and genital herpes are common among women of childbearing age, determines the urgency of enhancing the effectiveness of the treatment of these conditions. Purpose – evaluation of probiotics efficacy in complex therapeutic and preventive measures for pregnant women with herpesvirus infection. Patients and methods. The main group – 30 pregnant women with herpes infection to whom the complex of preventive measures with Florium probiotic containing 4 strains of lactobacilli was used; the comparison group – 30 pregnant women with prenatal care according to the Ministry of Health reports. The microscopic and cultural methods of examination were used in the studies of vaginal microecology. The intestine biocenosis disturbance level was evaluated by using cultural method and standard techniques. Results. There was observed the reduction of opportunistic pathogens in the intestine (hemolytic Escherichia coli, Proteus, Staphylococcus aureus, Klebsiella and Candida) against the background of the increase of dominant flora (increased concentration of Bifidoand Lactobacillus). The incidence of complaints was decreased by 3 times (bloating, discomfort, constipation, mucus in the stool). The microbial landscape of the vagina has been improved: the incidence of Lactobacillus seeding was increased by 3 times; seeding rate pathogenic and opportunistic pathogens was reduced (Staphylococcus aureus and hemolytic, Gardnerellas, Chlamydia, Ureaplazma, Mycoplasma and Candida). The incidence of complaints was reduced by 2–3 times (excessive vaginal discharge, itching, swelling and redness of the mucosa). The 2-fold reduced incidence of placental insufficiency and pre-eclampsia as well as fetal distress testifies to the improvement of conditions for development of gestational process. Conclusions. The results of efficacy and safety of probiotics in the complex treatment of pregnant women with herpes infection, allow us to recommend them for use in antenatal clinics and maternity homes.