The role of endothelial glycocalyx in sepsis | Zendy

INyoman Budi Hartawan | Zendy; Made Wiryana | Zendy

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The role of endothelial glycocalyx in sepsis

Author(s) -

INyoman Budi Hartawan,

Made Wiryana

Publication year - 2019

Publication title -

bali journal of anesthesiology

Language(s) - English

Resource type - Journals

ISSN - 2549-2276

DOI - 10.15562/bjoa.v3i1.114

Subject(s) - glycocalyx , hyaluronic acid , microbiology and biotechnology , heparan sulfate , glycosaminoglycan , chondroitin sulfate , chemistry , endothelial stem cell , endothelium , immunology , biochemistry , biology , anatomy , in vitro , endocrinology

The surface of endothelial cells is filled with various membrane-bound molecules that form the glycocalyx. The endothelial glycocalyx is a surface layer mainly consisted of glycosaminoglycans that include heparan sulfate, chondroitin sulfate, and hyaluronic acid and its core proteins. Previous studies suggest that endothelial surface glycocalyx shedding could play a role in endothelial dysfunction and inflammation. This article will review the endothelial glycocalyx and its role in sepsis.

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