The complement system: History, pathways, cascade and inhibitors | Zendy

Prabhu Nesargikar | Zendy; O. Brad Spiller | Zendy; Rafael Chavez | Zendy

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The complement system: History, pathways, cascade and inhibitors

Author(s) -

Prabhu Nesargikar,

O. Brad Spiller,

Rafael Chavez

Publication year - 2012

Publication title -

european journal of microbiology and immunology

Language(s) - English

Resource type - Journals

eISSN - 2062-8633

pISSN - 2062-509X

DOI - 10.1556/eujmi.2.2012.2.2

Subject(s) - complement system , complement (music) , medicine , neuroscience , transplantation , classical complement pathway , alternative complement pathway , intensive care medicine , immunology , biology , immune system , biochemistry , complementation , gene , phenotype

Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.

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