Advances on the toxicity of the cereal contaminant Fusarium esadepsipeptides

Fusarium head blight (FHB) of cereals is a well known disease caused by a complex of several\udtoxigenic species of Fusarium. FHB can reduce grain yield and quality, because of the accumulation of\udmycotoxins in cereal grains and derived foods and feeds. The pathogen mainly reported as causal agent of\udFHB is F. graminearum, that produces Deoxynivalenol (DON), the mycotoxin mostly associated to the\uddisease. However in the last decade, in Europe, in addition to DON, the esadepsipeptides Enniatins (ENs) and\udBeauvericin (BEA) have been often reported as cereal contaminants, in association with different species such\udas F. avenaceum, F. poae, and F. tricinctum. The natural occurrence of high amounts of BEA and ENs in\udFHB small grains, evaluated with the phytotoxic and zootoxic properties of these metabolites, compel to an\udexamination of their potential role in contributing to the severity of FHB. On the other hand, the recent studies\udthat have provided further data on the biological role of the esadepsipeptide in plants and their toxicity toward\udplants, animal and humans, make it worthwhile to expand the knowledge on the significance and the toxicity\udof these frequent contaminants of cereals