Open AccessSafe Use of Nitromethane for Aldol Reactions in Flow
Author(s) -
Matthew Hutchings,
Thomas Wirth
Publication year - 2016
Publication title -
journal of flow chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.916
H-Index - 25
eISSN - 2063-0212
pISSN - 2062-249X
DOI - 10.1556/1846.2016.00022
Subject(s) - nitromethane , aldol reaction , nitroaldol reaction , flow chemistry , chemistry , nanochemistry , organic chemistry , catalysis , combinatorial chemistry , enantioselective synthesis
Using a simple flow reactor, the safe use of nitromethane at elevated reaction temperatures was demonstrated in a nitroaldol reaction of different aldehydes. The reaction products were isolated in good yields after a short reaction time.
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