Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions | Zendy

Leandro H. Andrade | Zendy; Bruno A. Sousa | Zendy; Timothy F. Jamison | Zendy

Open Access

Confining a Biocatalyst for Highly Efficient and Selective Synthesis of Carboxamide Derivatives under Continuous-Flow Conditions

Author(s) -

Leandro H. Andrade,

Bruno A. Sousa,

Timothy F. Jamison

Publication year - 2016

Publication title -

journal of flow chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.916

H-Index - 25

eISSN - 2063-0212

pISSN - 2062-249X

DOI - 10.1556/1846.2016.00008

Subject(s) - biocatalysis , selectivity , carboxamide , flow chemistry , chemistry , combinatorial chemistry , nanochemistry , green chemistry , continuous flow , organic chemistry , catalysis , biochemical engineering , nanotechnology , materials science , reaction mechanism , engineering

The confinement of a biocatalyst designed to operate under continuous-flow conditions is a strategy developed by nature in order to achieve efficient reactions in biological media. Herein, we present a mimetic model that employs a confined lipase (CAL-B) in the production of several carboxamide derivatives from esters as precursors. The remarkable selectivity of such system is also described when α,β-unsatured carboxylic substrates are employed.

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