HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide | Zendy

Huba Kalász | Zendy; Attila Hunyadi | Zendy; Kornélia Tekes | Zendy; Rafael Dolesal | Zendy; Gellért Karvaly | Zendy

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HPLC analysis and blood-brain penetration of 20-hydroxyecdysone diacetonide

Author(s) -

Huba Kalász,

Attila Hunyadi,

Kornélia Tekes,

Rafael Dolesal,

Gellért Karvaly

Publication year - 2016

Publication title -

acta chromatographica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.316

H-Index - 28

eISSN - 2083-5736

pISSN - 1233-2356

DOI - 10.1556/1326.2017.29.3.07

Subject(s) - 20 hydroxyecdysone , penetration (warfare) , high performance liquid chromatography , chemistry , chromatography , in vivo , pharmacology , biochemistry , medicine , biology , microbiology and biotechnology , operations research , engineering , gene

Blood-brain penetration of 20-hydroxyecdysone 2,3;20,22-diacetonide (20DA) has been scouted using chromatographic methods. In vivo experiments were performed by treating male Wistar rats intraperitoneally (i.p.) with a dose of 50 mg kg−1 20DA. Control experiment was done by using 20-hydroxyecdysone (20E). Definite brain penetration of 20DA was found by using high-performance liquid chromatography (HPLC), while 20E does not show this type of distribution.

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