Influence of Diclofenac Sodium on Biochemical Indicators of Stomach Mucosa Conditions Against the Background of Excess and Deficiency of Hydrogen Sulfide in Rats | Zendy

Н. І. Волощук | Zendy; И. В. Таран | Zendy; Andrey Melnik | Zendy

Open Access

Influence of Diclofenac Sodium on Biochemical Indicators of Stomach Mucosa Conditions Against the Background of Excess and Deficiency of Hydrogen Sulfide in Rats

Author(s) -

Н. І. Волощук,

И. В. Таран,

Andrey Melnik

Publication year - 2015

Publication title -

the advanced science journal

Language(s) - English

Resource type - Journals

eISSN - 2219-7478

pISSN - 2219-746X

DOI - 10.15550/asj.2015.01.036

Subject(s) - hydrogen sulfide , stomach , diclofenac sodium , gastric mucosa , medicine , sodium , gastroenterology , chemistry , chromatography , organic chemistry , sulfur

In this article the effect of diclofenac sodium on biochemical parameters of gastric mucosa against the background of deficit and excess of hydrogen sulfide in rats was investigated. It turned out that such NSAIDs increased the process of peroxidation of lipid and protein and caused an imbalance in the system of antioxidant, disturbed the phospholipid spectrum and reduced mucus production of glycosaminoglycans in stomach. Administration of diclofenac sodium against background of H 2S deficit is accompanied by an increasing of range of these changes in metabolic processes in gastric mucosa, while its use with H 2S donor normalizes the course of biochemical processes in gastric mucosa.

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