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In this article the effect of diclofenac sodium on biochemical parameters of gastric mucosa against the background of deficit and excess of hydrogen sulfide in rats was investigated. It turned out that such NSAIDs increased the process of peroxidation of lipid and protein and caused an imbalance in the system of antioxidant, disturbed the phospholipid spectrum and reduced mucus production of glycosaminoglycans in stomach. Administration of diclofenac sodium against background of H 2S deficit is accompanied by an increasing of range of these changes in metabolic processes in gastric mucosa, while its use with H 2S donor normalizes the course of biochemical processes in gastric mucosa.

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Influence of Diclofenac Sodium on Biochemical Indicators of Stomach Mucosa Conditions Against the Background of Excess and Deficiency of Hydrogen Sulfide in Rats