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PURPOSE: Adipose tissue is a major source of glycerol which is one of the substrates for gluconeogenesis. Glycerol production and its effluence from adipose tissue to the liver are key to regulate lipid and glucose homeostasis. Aquaporin 7 (AQP7) is an aquaglyceroporin that plays as the adipose glycerol channel. In addition, aquaporin 9 (AQP9) is also the specific glycerol channel in the liver. In this study, we investigated AQP7 (A953G, V59L) and AQP9 (T279A, C43T) polymorphisms in patients with obese and/or type 2 diabetes mellitus (T2DM). METHODS: A hundred and ninety-eight volunteers divided into 3 groups: Group 1 (n=49, BMI 0,005). CONCLUSIONS: AQP7 (A953G, V59L) and AQP9 (T279A, C43T) gene polymorphisms seemed to be ineffective in the pathophysiology of obesity and type 2 diabetes.

Gene polymorphisms of water and glycerol channels aquaporin 7 and 9 in obese and/or diabetic patients