Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets | Zendy

Rohini Gomathinayagam | Zendy; Ji Hee Ha | Zendy; Muralidharan Jayaraman | Zendy; Yong Sang Song | Zendy; Ciro Isidoro | Zendy; Danny N. Dhanasekaran | Zendy

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Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Author(s) -

Rohini Gomathinayagam,

Ji Hee Ha,

Muralidharan Jayaraman,

Yong Sang Song,

Ciro Isidoro,

Danny N. Dhanasekaran

Publication year - 2020

Publication title -

journal of cancer prevention

Language(s) - English

Resource type - Journals

eISSN - 2288-3657

pISSN - 2288-3649

DOI - 10.15430/jcp.2020.25.3.136

Subject(s) - thymoquinone , nigella sativa , compendium , pharmacology , chemistry , cancer , cancer research , metastasis , computational biology , medicine , traditional medicine , biology , biochemistry , antioxidant , archaeology , history

Thymoquinone (TQ) is a bioactive component derived from the seeds of Nigella sativa that are commonly as black cumin. Evidences indicate that the medicinal properties of TQ have been recognized for more than 2000 years. TQ has been shown to possess potent chemopreventive properties that include anti-inflammatory and anti-neoplastic activities. Recent studies have unraveled the multiple mechanisms through which TQ exerts its chemopreventive and anticancer activity in different cancer cells in a contextual manner. The present review aims to provide a brief compendium on the molecular mechanisms through which TQ inhibits signaling pathways underlying cancer genesis, progression, and metastasis.

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