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Experimental studies were conducted on the basis of the Research Center for Biosafety and Environmental Control of Resources of the Agroindustrial Complex of the Dnipro SAEU, poultry farms of different directions of productivity of Donetsk-Prydniprovsky region of Ukraine in the period from 2016 to 2019. The purpose of the work is to determine the nature of pathomorphological changes and the status of systemic immunity in chickens with respiratory mycoplasmosis at poultry farms with various production. To determine the immunodeficiency and immunopathological conditions of a productive poultry with respiratory mycoplasmosis, a comprehensive immunological study was performed. Significant fluctuations in the absolute and relative values of leukograms and immunograms have been established, indicating a significant immunological alteration in chickens with respiratory mycoplasmosis. The most significant changes in the status of systemic immunity are found in chickens with respiratory mycoplasmosis at poultry farms with meat production, which are subject to more longer and more intense influence of human activity.Key words: Respiratory mycoplasmosis; Productive poultry; Immunity; Factors of human activity; ImmunopathologyReferencesAbbas, N., Suleman, M., Muhammad, N., Ahmad, K.N., Ali, I., Rauf, M., u0026 Rahman, S. (2018). Prevalence of Mycoplasma gallisepticum in poultry and wild life birds suspected of chronic respiratory disease in northern Pakistan. Journal Zoology, 50(3), 1071–1077. doi: 10.17582/journal.pjz/2018.50.3.1071.1077.Abbas, N., Suleman, M., Muhammad, N., Rahman, S., Ahmad, K.N., Tariq, N.A., Khalid, A., u0026 Faheem, J. (2018). Seropositivity, involvement in suspected cases of chronic respiratory diseases and comparative efficacy of various sero-diagnostic tests of Mycoplasma gallisepticum. 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Systemic immunity of chickens with respiratory mycoplasmosis at poultry farms with various production