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Patients with chronic limb-threatening ischaemia (CLTI), also known as critical limb ischaemia, secondary to infrainguinal occlusive disease have multiple treatment options. The historic gold standard of lower extremity surgical revascularisation has recently been challenged by endovascular therapy. Generally associated with lower rates of significant life-threatening and limb-threatening complications than open surgical methods, endovascular lower extremity revascularisation offers an alternative strategy for treating complex CLTI patients.

BEST Endovascular Versus Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI) Trial